The developmental capacity of nuclei "The developmental capacity of nuclei by Defined Factors in Cell 131, No. 5, 30 November 2007, pp. 861-872

Massachusetts: Cell Press, 2007. 1st Edition. FIRST EDITION IN ORIGINAL WRAPS of Takahashi and Yamanaka's 2007 Nobel Prize winning paper in which the authors described a pioneering technique for reprogramming adult human cells into a pluripotent state, meaning they could transform mature, specialized cells back into a state where they could potentially develop into any type of cell in the body.

The key innovation of their work was the identification of a set of transcription factors capable of inducing pluripotency in somatic cells. Specifically, they found that by introducing four transcription factors (Oct4, Sox2, Klf4, and c-Myc) into adult human fibroblast cells, they could reprogram these cells into what they termed "induced pluripotent stem cells" (iPSCs). These iPSCs exhibited characteristics similar to embryonic stem cells, including the ability to differentiate into various cell types.

This discovery represented a significant advancement in the field of regenerative medicine, as it offered a potential alternative to embryonic stem cells for studying development and disease, as well as for therapeutic applications. iPSCs provided a non-controversial and potentially patient-specific source of pluripotent cells, with the potential for use in tissue regeneration, disease modeling, drug discovery, and personalized medicine.

Takahashi and Yamanaka's paper has had a profound impact on biomedical research and regenerative medicine. CONDITION & DETAILS: Illustrated throughout. Quarto (11 x 8 inches; 275 x 200mm). Original paper wraps in near pristine condition inside and out. Clean and bright.