Aromatase Inhibitors Paperback - 2008
by Contribution by Angela Brodie; B. J. Furr (Editor); Contribution by Aman Buzdar
From the rear cover
Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase).
Whereas the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.
Details
- Title Aromatase Inhibitors
- Author Contribution by Angela Brodie; B. J. Furr (Editor); Contribution by Aman Buzdar
- Binding Paperback
- Edition 2nd
- Pages 189
- Volumes 1
- Language ENG
- Publisher Birkhauser
- Date 2008-02
- Illustrated Yes
- ISBN 9783764386924 / 3764386924
- Weight 1.1 lbs (0.50 kg)
- Dimensions 9.38 x 6.73 x 0.44 in (23.83 x 17.09 x 1.12 cm)
- Dewey Decimal Code 610
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