Insights Into Receptor Function and New Drug Development Targets Hardcover - 2006
by P. Michael Conn (Editor); Claude Kordon (Editor)
From the rear cover
G-Protein Coupled receptors (GPCRs) and other receptors are significant targets for drug discovery, due to their roles in fundamental physiological processes. Among these roles are: regulation of growth, food intake, reproduction, water balance, sensory perception, blood pressure and heart rate. GPCR-directed drugs account for approximately $40 billion in sales and, of drugs at market, approximately 70% target GPCR function.
The availability of combinatorial chemistry coupled with high throughput screening techniques have facilitated discovery of peptidic and non-peptidic ligands of membrane receptors. Mutant receptor models have revealed their role in health and disease and provided insight to new therapeutic approaches, based on control of protein trafficking. Understanding receptor-receptor interactions has provided one mechanism for receptor cross-talk and revealed unexpected interactions.
The completion of the human genome has identified a new source of therapeutic targets: "orphan receptors" with unknown functions and yet-to-be discovered ligands. Some orphans have now been identified as ghrelin, nociceptin, apelin, and urocortin. This finding, along with important technologies to develop ligands with desirable characteristics, including peptidomimetics is likely to further accelerate interest in this area.
Details
- Title Insights Into Receptor Function and New Drug Development Targets
- Author P. Michael Conn (Editor); Claude Kordon (Editor)
- Binding Hardcover
- Edition Us Edition
- Pages 202
- Volumes 1
- Language ENG
- Publisher Springer, Berlin, Germany
- Date 2006-07-25
- ISBN 9783540344469 / 3540344462
- Weight 0.58 lbs (0.26 kg)
- Dimensions 9.52 x 6.27 x 0.53 in (24.18 x 15.93 x 1.35 cm)
- Dewey Decimal Code 610
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Insights Into Receptor Function And New Drug Development Targets
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Insights into Receptor Function and New Drug Development Targets
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INSIGHTS INTO RECEPTOR FUNCTION AND NEW DRUG DEVELOPMENT TARGETS
by MICHAEL CONN, C. KORDON, Y. CHRISTEN,
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Insights into Receptor Function and New Drug Development Targets (Research and Perspectives in Endocrine Interactions)
by Conn, P. Michael [Editor]; Kordon, Claude [Editor];
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