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Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment
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Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy Hardcover - 2008

by Foreword by C. -H Heldin; Sonia B. Jakowlew (Editor)


From the publisher

Transforming Growth Factor-B in Cancer Therapy, Volume II: Cancer Treatment and Therapy The chapters in this volume confer an abundance of knowledge about the current state ofour understanding oftransforming growth factor-B (TGF-B) in cancer treatment and therapy. Unlike several more traditional positive polypeptide growth factors that stim- ulate cellular proliferation, the prototypical TGF-B is now known to inhibit the growth of most normal cell types, including those of epithelial and mesenchymal origin. However, there are examplesofcell types that can be stimulated by TGF-B under certain conditions. TGF-B also induces the accumulation of matrix molecules by stimulating their synthesis as well as inhibiting their degradation. Moreover, TGF-B induces apoptosis of certain cell types, thereby restricting their proliferation. OveractivityofTGF- has been linked to several diseases. For instance, the effect ofTGF- on matrix accumulation contributes to fibrotic conditions, like glomerulonephritis, lung fibrosis and liver cirrhosis (1). TGF- has a very complicated role in cancer that is only beginning to be understood.

From the rear cover

Transforming Growth Factor-� in Cancer Therapy, Volumes 1 and 2, provides a compendium of findings about the role of transforming growth factor-� (TGF-�) in cancer treatment and therapy. The second volume, Cancer Treatment and Therapy, is divided into three parts. Part I examines transforming growth factor-� in developing and advanced cancers. Part II details transforming growth factor-� in cancer treatment and therapy. Part III includes an investigation into the development of inhibitors of transforming growth factor-� signaling for therapy.

This volume's companion, Basic and Clinical Biology, examines transforming growth factor-� signaling in normal physiology, cancer pathobiology, normal and tumor biology, and inflammation and fibrosis. Together, Transforming Growth Factor-� in Cancer Therapy, Volumes 1 and 2, provide researchers and clinicians with a comprehensive and cutting-edge reference for the findings about the role of transforming growth factor-� in biology and cancer treatment.

Details

  • Title Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy
  • Author Foreword by C. -H Heldin; Sonia B. Jakowlew (Editor)
  • Binding Hardcover
  • Edition U. S. EDITION
  • Pages 786
  • Volumes 1
  • Language ENG
  • Publisher Humana
  • Date 2008
  • Illustrated Yes
  • ISBN 9781588297150 / 1588297152
  • Weight 4 lbs (1.81 kg)
  • Dimensions 9.92 x 7.34 x 1.35 in (25.20 x 18.64 x 3.43 cm)
  • Library of Congress subjects Carcinogenesis, Transforming growth factors-beta
  • Dewey Decimal Code 571.6

Media reviews

Citations

  • Scitech Book News, 06/01/2008, Page 67
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Transforming Growth Factor-Beta in Cancer Therapy, Volume II: Cancer Treatment and Therapy
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