Barile's Clinical Toxicology: Principles and Mechanisms Hardcover - 2019

Frank A. Barile, PhD, is Professor in the Toxicology Division and past chairman

of the Department of Pharmaceutical Sciences, St. John's University College of

Pharmacy and Health Sciences, New York.

Dr. Barile received his BS in Pharmacy, MS in Pharmacology, and PhD in

Toxicology at St. John's University. After doing a postdoctoral fellowship in

Pulmonary Pediatrics at the Albert Einstein College of Medicine, Bronx, NY, he

moved to the Department of Pathology, Columbia University--St. Luke's Roosevelt

Hospital, NY, as a research associate. In these positions, he investigated the role of

pulmonary toxicants in collagen metabolism in cultured lung cells. In 1984, he was

appointed assistant professor in the Department of Health Sciences at City University

of NY. Sixteen years later, he rejoined St. John's University in the Department of

Pharmaceutical Sciences in the College of Pharmacy.

Dr. Barile holds memberships in several professional associations, including the

U.S. Society of Toxicology, the American Association of University Professors, the

American Association for the Advancement of Science, the American Society of

Hospital Pharmacists, New York City Pharmacists Society, New York Academy of

Sciences, and New York State Council of Health System Pharmacists. He is past

president of the In Vitro and Alternative Methods Specialty Section of the U.S.

Society of Toxicology and a former member of the Scientific Advisory Committee

for Alternative Toxicological Methods, the National Institute of Environmental

Health Sciences, U.S. National Institutes of Health (NIH). He is former editor of

by Elsevier Ltd.

Dr. Barile is the recipient of Public Health Service research grants from the

National Institute of General Medical Sciences, the National Institutes of Health,

and grants from private foundations dedicated to alternatives to animal testing.

He has authored approximately 100 original research manuscripts, review articles,

research abstracts, and conference proceedings in peer-reviewed toxicology and biomedical

journals. He has also published several books and related chapters in the

field. He contributed original in vitro toxicology data to the international Multicenter

Evaluation for In Vitro Cytotoxicity program. He lectures regularly to pharmacy and

toxicology undergraduate and graduate students in clinical and basic pharmaceutical

and toxicological sciences and was awarded "Professor of the Year" for the College

of Pharmacy by the St. John's University Student Government Association (2003).

Dr. Barile has served on several U.S. government advisory committees, including:

Toxicology Assessment Peer Review Committee, U.S. Environmental Protection

Agency; National Institutes of Health Review Panel, Study Section Reviewer (2013);

Scientific Advisory Committee on Alternative Toxicological Methods (SACATM,

2005-2009); National Toxicology Program (NTP) Interagency Center for the

Evaluation of Alternative Toxicological Methods, Support Contract Reviewer (2014);

U.S. Food and Drug Administration (U.S. FDA), National Center for Toxicology

Research, Systems Biology Subcommittee (2016); National Institute for Occupational

Safety and Health (NIOSH) and Oak Ridge Associated Universities, SK Profiles

Review Group (2014); U.S. Food and Drug Administration advisory committee on

alternative toxicological methods (2013); and has served as vice president of the

Dermal Toxicology Specialty Section for the Society of Toxicology (2013-2014).

Dr. Barile received the Faculty Recognition Award, American Association of

University Professors Faculty Association Award, St. John's University, in 2003,

2004-2005, 2013-2014, and 2015-2016 and received the prestigious Public Health

Service Medallion from the director of the National Institute of Environmental

Health Sciences, Dr. Linda Birnbaum, for contributions to the Scientific Advisory

Committee for Alternative Toxicological Methods (2009).

Dr. Barile continues original research on the cytotoxic effects of therapeutic

drugs, environmental chemicals, and controlled substances on cultured mammalian

embryonic stem cells and human induced pluripotent stem cells and has dedicated

his professional life to the advancement of in vitro alternative methods to reduce,

replace and refine animal toxicology testing.