Feeding Experiments Illustrating the Importance of Accessory Factors in Normal Dietaries by HOPKINS, Frederick Gowland - 1912

London: Cambridge University Press, 1912. 1st Edition. Hardcover. Very Good. 1st Edition. Hardcover. 8vo - over 7¾ - 9¾" tall. In: Journal of Physiology, Vol. XLIV, Nos. 5 and 6, pp. 425-460. London: Cambridge University Press, 1912. 8vo (229 x 162 mm). Entire volume, 513, [25] pp. Bound in early 20th century beige library cloth, spine titled in black. Text generally clean with little yellowing, a few early leaves somewhat wrinkled (but unstained). Hopkin's paper with chipping of a few mm of upper corner well outside text area. Provenance: Springfield College, Babson Library (bookplate to front pastedown). Very good copy in the rare entire volume. ----

PMM 404; Garrison Morton 1048. FIRST EDITION of Hopkins' landmark paper. Hopkins was already convinced that certain 'accesory factors' were essential to the health and growth of animals, and on returning to work he discovered that rats who declined and died on what appeared adequate feeding throve when small quantities of milk were added to their diet. In 1912, in the paper cited, he made the pronouncement upon which all subsequent vitamin research is based: that 'accessory factors' are essential to nutrition. Entire journal volumes are rarely seen on the market. We can trace only one copy sold at auction in the past 20 years (Sotheby's sale N07732, 2001, lot 92, sold USD 10,200). - Visit our website for additional images and information.