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Glycogen Synthase Kinase 3 (Gsk-3) and Its Inhibitors: Drug Discovery and Development Hardcover - 2006 - 1st Edition
by Ana Martinez (Editor); Ana Castro (Editor); Miguel Medina (Editor)
From the rear cover
Glycogen Synthase Kinase 3 (GSK-3) was discovered about twenty-five years ago but had garnered little interest until recently. Now many researchers believe that there is much potential for this "old" enzyme and are re-examining its biological characteristics. GSK-3 and its inhibitors could lead to effective treatments for neurogenerative disorders, type II diabetes, depression and bipolar disorder, and some forms of cancer. This book explores the nature of this promising enzyme, providing a thorough introduction and discussion, and mentions the birth of several chemical families of GSK-3 inhibitors with varying selectivity.
Specific topics relating to GSK-3 covered in this book include:
- Cellular functions
- Neuronal cell biology
- Crystal structures
- Kinase-kinase and site-site interactions in the phosphorylation of tau
- Therapeutic target in human pathology
- Role in stem cells
- Physiology studies
- Development and therapeutic potential of GSK-3 inhibitors
Gathering and systematically analyzing relevant and up-to-date information about GSK-3 and its known inhibitors, this book will aid researchers interested in drug design and development, especially those directly involved in the fascinating world of GSK-3.
Details
- Title Glycogen Synthase Kinase 3 (Gsk-3) and Its Inhibitors: Drug Discovery and Development
- Author Ana Martinez (Editor); Ana Castro (Editor); Miguel Medina (Editor)
- Binding Hardcover
- Edition number 1st
- Edition 1
- Pages 384
- Volumes 1
- Language ENG
- Publisher Wiley-Interscience
- Date October 20, 2006
- Illustrated Yes
- Features Bibliography, Illustrated, Index, Table of Contents
- ISBN 9780471770015 / 0471770019
- Weight 1.47 lbs (0.67 kg)
- Dimensions 9.3 x 6.38 x 0.94 in (23.62 x 16.21 x 2.39 cm)
- Library of Congress subjects Glycogen synthase kinase-3, Glycogen synthase kinase-3 - Inhibitors
- Library of Congress Catalog Number 2006007195
- Dewey Decimal Code 572.567
About the author
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Glycogen Synthase Kinase 3 (GSK-3) and Its Inhibitors: Drug Discovery and Development
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