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Mass Spectrometry in Drug Metabolism and Pharmacokinetics
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Mass Spectrometry in Drug Metabolism and Pharmacokinetics Hardcover - 2008

by Ragu Ramanathan (Editor)


From the publisher

Includes bibliographical references and index.

From the rear cover

Advanced mass spectrometry techniques to support your drug discovery and development research

Inside this book are a host of practical tools and techniques that enable you to fully leverage the capabilities of mass spectrometry in order to get the most out of drug metabolism and pharmacokinetics studies. You'll learn the latest applications for determining how a drug is absorbed, distributed, metabolized, and excreted by the body.

Logically organized, Mass Spectrometry in Drug Metabolism and Pharmacokinetics starts off with an overview of the role of mass spectrometry in drug discovery and development. It then shows you how to perform routine applications before introducing you to sophisticated tools and techniques for solving complex drug metabolism and pharmacokinetics problems. Throughout the book, the main focus is on the use of LC-MS and MALDI-MS.

Each chapter has been written by one or more leading experts who share their own first-hand laboratory experience. You'll gain a wealth of tips for performing successful analyses as well as avoiding common pitfalls. Moreover, the book is packed with features that help you grasp new concepts quickly and put your knowledge into practice, including:

  • Figures and illustrations to help you understand how to perform specific techniques and applications

  • Charts and tables that serve as quick summaries and reference guides

  • Coverage of the latest tested-and-proven techniques

  • References leading to the primary literature in the field

Carefully edited to ensure thoroughness and a uniform standard of quality, this book is sure to help you advance your own important drug research efforts.

Details

  • Title Mass Spectrometry in Drug Metabolism and Pharmacokinetics
  • Author Ragu Ramanathan (Editor)
  • Binding Hardcover
  • Edition US Edition
  • Pages 408
  • Volumes 1
  • Language ENG
  • Publisher Wiley, New Delhi
  • Date June 2, 2008
  • Illustrated Yes
  • Features Bibliography, Illustrated, Index, Table of Contents
  • ISBN 9780471751588 / 0471751588
  • Weight 1.45 lbs (0.66 kg)
  • Dimensions 9.1 x 6.1 x 0.9 in (23.11 x 15.49 x 2.29 cm)
  • Library of Congress subjects Drug Design, Pharmacokinetics
  • Library of Congress Catalog Number 2008021424
  • Dewey Decimal Code 615.7

Media reviews

Citations

  • Scitech Book News, 06/01/2009, Page 119

About the author

Ragu Ramanathan received a B.Sc. in Chemistry from the University of Southern Mississippi and a Ph.D. in Physical Chemistry/Mass Spectrometry from the University of Florida. His graduate research focused on coupling of electrospray ionization (ESI) to Fourier transform ion cyclotron resonance (FTICR) mass spectrometer. After spending three years as a postdoctoral research fellow with Professor Michael L. Gross at the Washington University, St. Louis, Missouri, Dr. Ramanathan managed the Center for Advanced Mass Spectrometry at the Analytical Bio-Chemistry Laboratories, Columbia, Missouri. In 1998, Dr. Ramanathan joined Schering-Plough Research Institute's (SPRI) Drug Metabolism and Pharmacokinetics (DMPK) Department and completed his tenure as a senior principal scientist in 2008. While at SPRI, Dr. Ramanathan was involved in the application of LC-MS for profiling and characterization of metabolites of drug candidates in the preclinical development and clinical stages. Dr. Ramanathan was with Pfizer Global Research and Development from 1999 to 2002 as a group leader of the Ann Arbor site biotransformation group. Dr. Ramanathan is currently an associate director at the Bristol-Myers Squibb, Co. and is responsible for elucidating biotransformation pathways of development drug candidates. Dr. Ramanathan's accomplishments include 35 peer-reviewed papers, 10 book chapters, and over 60 oral/poster presentations. He also served as a chairperson for the North Jersey ACS Mass Spectrometry Discussion Group and as a chairman for DMPK sessions of the American Society for Mass Spectrometry and Eastern Analytical Symposium meetings.
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