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Ubiquitin Proteasome System in the Central Nervous: From Physiology to Pathology
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Ubiquitin Proteasome System in the Central Nervous: From Physiology to Pathology -2008 Update Hardcover - 2010 - 1st Edition

by Di Napol Mario Ed


From the publisher

The ubiquitin-proteasome field has experienced a breathtaking development from obscure origins in the late 1970s and early 1980s, through a maturing but a well circumscribed field in the 1990s, into a huge, and ever growing interdisciplinary area in the 2000s. Nearly 7% of all genes encoded by the human genome comprise elements of the ubiquitin-proteasome system (UPS), making it the most complex of all biochemical pathways. This complexity depends mostly on its hierarchical organization, where the 20S proteasome is the common machinery mediating total or partial degradation of practically any protein in our body. Proteolysis via the UPS is a rapid and effective method of degrading a specific protein at a specific time, and in many cases a protein is degraded only in response to a particular cellular signal or event. Controlling where and when a protein is degraded can enhance the specificity and timing of proteolysis, generate asymmetry and maintain sub-compartments. The 24 articles of this updated collection describe the authors' research, from medical and academic research facilities worldwide, on various aspects of the UPS in nervous system. The articles discuss research of the UPS in connection with many important aspects of nervous system development, physiology and diseases, ranging from basic sciences to more specific topics useful for both basic neuroscientists and active clinical neurologists in an attempt to present in one place a cross-field, translational reference in a format accessible to a practicing neurologist as well as to a neuroscientist. Due to the inherent nature of the topic, the book has crossed over discipline barriers, engaging an amazing international team of specialists from disparate fields to conduct the readers across the principal avenues of the UPS physiology and pathology in the nervous system.

Details

  • Title Ubiquitin Proteasome System in the Central Nervous: From Physiology to Pathology -2008 Update
  • Author Di Napol Mario Ed
  • Binding Hardcover
  • Edition number 1st
  • Edition 1
  • Pages 552
  • Volumes 1
  • Language ENG
  • Publisher Nova Science Publishers
  • Date 2010-03
  • Illustrated Yes
  • ISBN 9781607416944 / 1607416948
  • Library of Congress subjects Central nervous system - Physiology, Central Nervous System Diseases - metabolism
  • Library of Congress Catalog Number 2009016908
  • Dewey Decimal Code 612.82
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The Ubiquitin Proteasome System in the Central Nervous System
Stock Photo: Cover May Be Different

The Ubiquitin Proteasome System in the Central Nervous System

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Nova Science Publishers, Incorporated , pp. xxiii + 552 Index Updated Edition . Hardback. Used.
Item Price
£106.35
£3.20 shipping to USA